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KMID : 1123920030170030777
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Korean Journal of Oriental Physiology and Pathology
2003 Volume.17 No. 3 p.777 ~ p.779
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In vitro Antimalarial Effect of Bamboo Family Aganist P. falciparum
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Park Hyun
Kim Myung-Soo
Jeon Byung-Hoon
Lee John-Hwa
Takaya Yoshiaki
Wataya Yusuke
Kim Hye-Sook
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Abstract
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Among extracts prepared from Alstonia scholaris, Phyllostachys pubescens and Bambusa veitchii, methanol fraction of Alstonia scholaris was found to have antiplasmodial effect by inhibiting growth of the chloroquine-resistant Plasmodium falciparum strain FCR-3 with less than 14 μg/ml of EC50 values. Methanol fraction 2 of Alstonia scholaris revealed the strongest anti plasmodial effect with 40 μg/ml of EC50 value. Especially, this fraction showed higher than 3-folds selective toxicity on a Plasmodium as the EC value was 116 μg/ml on the host FM3A cell. This is the first report on which an extract compound from Alstonia scholaris showed antimalarial effect.
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KEYWORD
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Plasmodium falciparum, Alstonia scholaris, antiplasmodial effect
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